Mod Organiser uses virtualisation, which means that it won't 'pollute' your data directory in Skyrim/FO4, essentially reducing more than 2/3 the size of used spaces while compared to NMM (since NMM stores the downloaded mods, virtual install files ready for overwriting, as well as extracting files into your data directory). I had to manually remove the check and recompile the specific module which is super unfriendly for non-technical majorities. esm, but all creation club's esl plugins are loaded before mod esms causing NMM to disallow you on sorting your plugins. esl support (on 0.63.17) is flawed anyway, it has a conditional check about disabling mod sorting if.
However, just as per K.B.' and have said the maximum size of one file in an archive should not be more than 2GB which is a severe limitation. NMM is easy to use as it is supported by the site itself such as direct download from the manager itself. However FOMM would be quite outdated for games such as Fallout 4/Skyrim.
